The death of Deadpool has been a long time coming. He's a popular character, and nothing says "popular" like a specially renumbered epic death event. Also, Marvel's sales head David Gabriel already told ComicBook.com months ago that Marvel was planning to kill off the character (or "a character with the word Dead in his name", but we didn't think it was going to be Dead Girl again), so the writing was on the wall for ol' Wade Wilson.
Now Marvel has confirmed to Nerdist that Deadpool will meet his end in Deadpool #250 (actually Deadpool #45) in April, in an issue that places the mercenary with a mouthcenary in a final confrontation with the jaunty beret-wearing goons of Ultimatum. The issue will be the last in the current series.